2012.03.18 Quiz: Anti-NMDA Receptor Antibody-Associated Encephalitis

Which of the following is incorrect about anti-N-methyl-D-aspartate receptor (NMDAR) antibody-associated encephalitis?
A. It is only associated with ovarian teratoma, and only occurs in female.
B. CSF shows lymphocytic pleocytosis and mildly elevated protein
C. NMDAR are highly expressed in the forebrain, limbic system and hypothalamus.
D. Besides seizures, psychiatric symptoms, short-term memory loss and autonomic instability, abnormal movement like orofacial dyskinesia is particularly striking.
E. Antibodies to NR1/NR2 receptors can be found in serum and CSF, and its clinical sensitivity and specificity is 100%