Scott E Kasner a, Steven R Levine b. The Lancet Neurology, Early Online Publication, 27 July 2010
Seven randomised, placebo-controlled trials combined in a recent pooled analysis 1 reported that thrombolysis with intravenous alteplase (recombinant tissue plasminogen activator; rt-PA) is efficacious in the treatment of acute ischaemic stroke.
The window of opportunity is up to 4·5 h after onset, although much earlier is much better. 2 There has been some concern as to whether the results of trials could be replicated in broad-based clinical practice, and support for such generalisability has come ...

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