2013 May - Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults

Schmidt M, Tachon G, Devilliers C, Muller G, Hekimian G, Bréchot N, Merceron S, Luyt CE, Trouillet JL, Chastre J, Leprince P, Combes A.; Intensive Care Med. 2013 May;39(5):838-46.

PURPOSE: This study was designed to optimize the latest generation venovenous (vv)-extracorporeal membrane oxygenation (ECMO)-circuit configuration and settings based on the evaluation of blood oxygenation and CO2 removal determinants in patients with severe acute respiratory distress syndrome (ARDS) on ultraprotective mechanical ventilation.

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2013 May - Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS : The prospective randomized Xtravent-study

Bein T, Weber-Carstens S, Goldmann A, Müller T, Staudinger T, Brederlau J, Muellenbach R, Dembinski R, Graf BM, Wewalka M, Philipp A, Wernecke KD, Lubnow M, Slutsky AS.; Intensive Care Med. 2013 May;39(5):847-56

BACKGROUND: Acute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator induced lung injury (VILI). We investigated the effects of a low tidal volume (V T) strategy (V T ≈ 3 ml/kg/predicted body weight [PBW]) using pumpless extracorporeal lung assist in established ARDS.

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2013 Apr - Microcirculatory blood flow as a tool to select ICU patients eligible for fluid therapy

Pranskunas A, Koopmans M, Koetsier PM, Pilvinis V, Boerma EC.; Intensive Care Med. 2013 Apr;39(4):612-9.

PURPOSE: The aim of this study is to assess the incidence of sublingual microcirculatory flow alterations, according to a predefined arbitrary cutoff value, in patients with "clinical signs of impaired organ perfusion". Secondary endpoints were the changes in microvascular flow index (MFI), "clinical signs of impaired organ perfusion", and stroke volume (SV) after fluid administration, and the differences between groups.

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2013 Apr - Predictors of external cooling failure after cardiac arrest

Ricome S, Dumas F, Mongardon N, Varenne O, Fichet J, Pène F, Zuber B, Vivien B, Charpentier J, Chiche JD, Mira JP, Cariou A.; Intensive Care Med. 2013 Apr;39(4):620-8.

PURPOSE: External cooling is largely employed to induce hypothermia in comatose survivors of cardiac arrest (CA), but can fail to reach the target temperature in a reasonable time. We aimed to assess the rate of failure of external cooling after CA and to determine failure predictors.

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2013 Apr - Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia

Martín-Loeches I, Bermejo-Martin JF, Vallés J, Granada R, Vidaur L, Vergara-Serrano JC, Martín M, Figueira JC, Sirvent JM, Blanquer J, Suarez D, Artigas A, Torres A, Diaz E, Rodriguez A; SEMICYUC/REIPI/CIBERES H1N1 Working Group.; Intensive Care Med. 2013 Apr;39(4):693-702.

PURPOSE: To determine whether macrolide-based treatment is associated with mortality in critically ill H1N1 patients with primary viral pneumonia.

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2013 Apr - Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy

Gattas DJ, Dan A, Myburgh J, Billot L, Lo S, Finfer S; CHEST Management Committee.; Intensive Care Med. 2013 Apr;39(4):558-68.

PURPOSE: To determine whether fluid resuscitation of acutely ill adults with 6 % hydroxyethyl starch (6 % HES 130) with a molecular weight of 130 kD and a molar substitution ratio of approximately 0.4 (6 % HES 130) compared with other resuscitation fluids results in a difference in the relative risk of death or treatment with renal replacement therapy (RRT).

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2013 Apr - Intubation-related tracheal ischemic lesions: incidence, risk factors, and outcome

Touat L, Fournier C, Ramon P, Salleron J, Durocher A, Nseir S.; Intensive Care Med. 2013 Apr;39(4):575-82.

PURPOSE:  To determine incidence, risk factors and outcome of tracheal ischemic lesions related to intubation.

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2013 Mar - Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?

Leal-Noval SR, Muñoz-Gómez M, Jiménez-Sánchez M, Cayuela A, Leal-Romero M, Puppo-Moreno A, Enamorado J, Arellano-Orden V.; Intensive Care Med. 2013 Mar;39(3):445-53
PURPOSE: This study was undertaken to investigate the efficacy of red blood cell transfusion (RBCT) at reversing the deleterious effects of moderate anemia in critically ill, non-bleeding patients.

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2013 Mar - Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis

Bellomo R, Lipcsey M, Calzavacca P, Haase M, Haase-Fielitz A, Licari E, Tee A, Cole L, Cass A, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Myburgh J, Scheinkestel C; RENAL Study Investigators and The ANZICS Clinical Trials Group.; Intensive Care Med. 2013 Mar;39(3):429-36
PURPOSE: In acute kidney injury patients, metabolic acidosis is common. Its severity, duration, and associated changes in mean arterial pressure (MAP) and vasopressor therapy may be affected by the intensity of continuous renal replacement therapy (CRRT). We aimed to compare key aspects of acidosis and MAP and vasopressor therapy in patients treated with two different CRRT intensities.

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2013 Mar - Five-year cost-utility analysis of acute renal replacement therapy: a societal perspective

Laukkanen A, Emaus L, Pettilä V, Kaukonen KM.; Intensive Care Med. 2013 Mar;39(3):406-13
PURPOSE: Assessment of the cost utility (CU) of acute renal replacement therapy (RRT) from a societal perspective during a 5-year follow-up.

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2013 Mar - Rising serum sodium levels are associated with a concurrent development of metabolic alkalosis in critically ill patients

Lindner G, Schwarz C, Grüssing H, Kneidinger N, Fazekas A, Funk GC.; Intensive Care Med. 2013 Mar;39(3):399-405
PURPOSE: Changes in electrolyte homeostasis are important causes of acid-base disorders. While the effects of chloride are well studied, only little is known of the potential contributions of sodium to metabolic acid-base state. Thus, we investigated the effects of intensive care unit (ICU)-acquired hypernatremia on acid-base state.

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2013 Mar - Value of lower respiratory tract surveillance cultures to predict bacterial pathogens in ventilator-associated pneumonia: systematic review and diagnostic test accuracy meta-analysis

Brusselaers N, Labeau S, Vogelaers D, Blot S.; Intensive Care Med. 2013 Mar;39(3):365-75
PURPOSE: In ventilator-associated pneumonia (VAP), early appropriate antimicrobial therapy may be hampered by involvement of multidrug-resistant (MDR) pathogens.

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2013 Jan - Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications

Matamis D, Soilemezi E, Tsagourias M, Akoumianaki E, Dimassi S, Boroli F, Richard JC, Brochard L.; Intensive Care Med. 2013 Jan 24. [Epub ahead of print]
The use of ultrasonography has become increasingly popular in the everyday management of critically ill patients. It has been demonstrated to be a safe and handy bedside tool that allows rapid hemodynamic assessment and visualization of the thoracic, abdominal and major vessels structures. More recently, M-mode ultrasonography has been used in the assessment of diaphragm kinetics. Ultrasounds provide a simple, non-invasive method of quantifying diaphragmatic movement in a variety of normal and pathological conditions...

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2013 Jan - Cognitive impairment after intensive care unit admission: a systematic review

Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D.; Intensive Care Med. 2013 Jan 18. [Epub ahead of print]
PURPOSE: There is increasing evidence that critical illness and treatment in an intensive care unit (ICU) may result in significant long-term morbidity. The purpose of this systematic review was to summarize the current literature on long-term cognitive impairment in ICU survivors.

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2013 Jan - Number of supervised studies required to reach competence in advanced critical care transesophageal echocardiography

Charron C, Vignon P, Prat G, Tonnelier A, Aegerter P, Boles JM, Amiel JB, Vieillard-Baron A.; Intensive Care Med. 2013 Jan 24. [Epub ahead of print]
PURPOSE: To determine the minimum number of supervised transesophageal echocardiography (TEE) that intensivists should perform to reach competence in performing and interpreting a comprehensive hemodynamic assessment in ventilated intensive care unit patients.

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2013 Jan - Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R; The Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup*. Intensive Care Med. 2013 Jan 30. [Epub ahead of print]
OBJECTIVE:  To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008.

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2013 Jan - Accuracy of plasma neutrophil gelatinase-associated lipocalin in the early diagnosis of contrast-induced acute kidney injury in critical illness

Valette X, Savary B, Nowoczyn M, Daubin C, Pottier V, Terzi N, Seguin A, Fradin S, Charbonneau P, Hanouz JL, du Cheyron D.; Intensive Care Med. 2013 Jan 30. [Epub ahead of print]
PURPOSE: Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker for acute kidney injury (AKI). We evaluated the diagnostic and prognostic accuracies of plasma NGAL (pNGAL) for contrast-induced AKI (CI-AKI) in critically ill patients.

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2013 Jan - A universal definition of ARDS: the PaO(2)/FiO (2) ratio under a standard ventilatory setting-a prospective, multicenter validation study

Villar J, Pérez-Méndez L, Blanco J, Añón JM, Blanch L, Belda J, Santos-Bouza A, Fernández RL, Kacmarek RM; Spanish Initiative for Epidemiology, Stratification, and Therapies for ARDS (SIESTA) Network. Intensive Care Med. 2013 Jan 31. [Epub ahead of print]
PURPOSE: The PaO(2)/FiO(2) is an integral part of the assessment of patients with acute respiratory distress syndrome (ARDS). The American-European Consensus Conference definition does not mandate any standardization procedure. We hypothesized that the use of PaO(2)/FiO(2) calculated under a standard ventilatory setting within 24 h of ARDS diagnosis allows a more clinically relevant ARDS classification.

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2013 Jan - Intermittent pneumatic compression to prevent venous thromboembolism in patients with high risk of bleeding hospitalized in intensive care units: the CIREA1 randomized trial

Vignon P, Dequin PF, Renault A, Mathonnet A, Paleiron N, Imbert A, Chatellier D, Gissot V, Lhéritier G, Aboyans V, Prat G, Garot D, Boulain T, Diehl JL, Bressollette L, Delluc A, Lacut K; The Clinical Research in Intensive Care and Sepsis Group (CRICS Group).; Intensive Care Med. 2013 Jan 31. [Epub ahead of print]
PURPOSE: Venous thromboembolism (VTE) is a frequent and serious problem in intensive care units (ICU). Anticoagulant treatments have demonstrated their efficacy in preventing VTE. However, when the bleeding risk is high, they are contraindicated, and mechanical devices are recommended. To date, mechanical prophylaxis has not been rigorously evaluated in any trials in ICU patients.

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2013 Feb - Clinical outcomes of Pseudomonas aeruginosa pneumonia in intensive care unit patients

Tumbarello M, De Pascale G, Trecarichi EM, Spanu T, Antonicelli F, Maviglia R, Pennisi MA, Bello G, Antonelli M.; Intensive Care Med. 2013 Feb 1. [Epub ahead of print]
PURPOSE: Our aim was to identify the clinical profile of intensive care unit (ICU) patients with Pseudomonas aeruginosa (PA) pneumonia and the impact on ICU mortality and duration of mechanical ventilation (MV) of multidrug resistance (MDR) in the PA isolate and inadequate initial antibiotic therapy (IIAT).

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