2013 Jan - Early change in blood glucose concentration is an indicator of mortality in critically ill children

Nayak PP, Davies P, Narendran P, Laker S, Gao F, Gough SC, Stickley J, Morris KP.; Intensive Care Med. 2013 Jan;39(1):123-8.
OBJECTIVE: Hyperglycaemia is associated with increased mortality in critically ill patients. A number of studies have highlighted an association between increased variability of blood glucose (BG) concentration and mortality, supporting a survival disadvantage if BG homeostasis is lost. By exploring the longitudinal BG profile of individual children over time, this study investigates the importance of intact homeostasis early after admission to the paediatric intensive care unit (PICU).

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2013 Jan - End-tidal carbon dioxide is better than arterial pressure for predicting volume responsiveness by the passive leg raising test

Monnet X, Bataille A, Magalhaes E, Barrois J, Le Corre M, Gosset C, Guerin L, Richard C, Teboul JL.; Intensive Care Med. 2013 Jan;39(1):93-100.
PURPOSE: In stable ventilatory and metabolic conditions, changes in end-tidal carbon dioxide (EtCO(2)) might reflect changes in cardiac index (CI). We tested whether EtCO(2) detects changes in CI induced by volume expansion and whether changes in EtCO(2) during passive leg raising (PLR) predict fluid responsiveness. We compared EtCO(2) and arterial pulse pressure for this purpose.

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2013 Jan - Safety of performing fiberoptic bronchoscopy in critically ill hypoxemic patients with acute respiratory failure

Cracco C, Fartoukh M, Prodanovic H, Azoulay E, Chenivesse C, Lorut C, Beduneau G, Bui HN, Taille C, Brochard L, Demoule A, Maitre B.; Intensive Care Med. 2013 Jan;39(1):45-52.
BACKGROUND: The safety of fiberoptic bronchoscopy (FOB) in nonintubated critically ill patients with acute respiratory failure has not been extensively evaluated. We aimed to measure the incidence of intubation and the need to increase ventilatory support following FOB and to identify predictive factors for this event.

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2013 Jan - An optimized set-up for helmet noninvasive ventilation improves pressure support delivery and patient-ventilator interaction

Mojoli F, Iotti GA, Currò I, Pozzi M, Via G, Venti A, Braschi A.;  Intensive Care Med. 2013 Jan;39(1):38-44.
OBJECTIVE: To test the effects on mechanical performance of helmet noninvasive ventilation (NIV) of an optimized set-up concerning the ventilator settings, the ventilator circuit and the helmet itself.

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2013 Jan - Alcohol withdrawal and delirium tremens in the critically ill: a systematic review and commentary

Awissi DK, Lebrun G, Coursin DB, Riker RR, Skrobik Y.; Intensive Care Med. 2013 Jan;39(1):16-30.
INTRODUCTION: Alcohol withdrawal is common among intensive care unit (ICU) patients, but no current practice guidelines exist. We reviewed published manuscripts for prevalence, risk factors, screening tools, prophylactic and treatment strategies, and outcomes for alcohol withdrawal syndrome (AWS) and delirium tremens (DT) in the critically ill.

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2013 Jan - Prophylactic protective ventilation: lower tidal volumes for all critically ill patients?

Lellouche F, Lipes J.; Intensive Care Med. 2013 Jan;39(1):6-15.
High tidal volumes have historically been recommended for mechanically ventilated patients during general anesthesia. High tidal volumes have been shown to increase morbidity and mortality in patients suffering from acute respiratory distress syndrome (ARDS). Barriers exist in implementing a tidal volume reduction strategy related to the inherent difficulty in changing one's practice patterns, to the current need to individualize low tidal volume settings only for a specific subgroup of mechanically ventilated patients (i.e., ARDS patients), the difficulty in determining the predicated body weight (requiring the patient's height and a complex formula)...

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2012 Nov - Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature

Lee JH, Rehder KJ, Williford L, Cheifetz IM, Turner DA. Intensive Care Med. 2012 Nov 10. [Epub ahead of print]

BACKGROUND: High flow nasal cannula (HFNC) systems utilize higher gas flow rates than standard nasal cannulae. The use of HFNC as a respiratory support modality is increasing in the infant, pediatric, and adult populations as an alternative to non-invasive positive pressure ventilation.

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2012 Nov - Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?

Leal-Noval SR, Muñoz-Gómez M, Jiménez-Sánchez M, Cayuela A, Leal-Romero M, Puppo-Moreno A, Enamorado J, Arellano-Orden V. Intensive Care Med. 2012 Nov 27. [Epub ahead of print]
PURPOSE: This study was undertaken to investigate the efficacy of red blood cell transfusion (RBCT) at reversing the deleterious effects of moderate anemia in critically ill, non-bleeding patients.

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2012 Nov - Value of lower respiratory tract surveillance cultures to predict bacterial pathogens in ventilator-associated pneumonia: systematic review and diagnostic test accuracy meta-analysis

Brusselaers N, Labeau S, Vogelaers D, Blot S.; Intensive Care Med. 2012 Nov 28. [Epub ahead of print]
PURPOSE: In ventilator-associated pneumonia (VAP), early appropriate antimicrobial therapy may be hampered by involvement of multidrug-resistant (MDR) pathogens.

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2012 Dec - Safety climate reduces medication and dislodgement errors in routine intensive care practice

Valentin A, Schiffinger M, Steyrer J, Huber C, Strunk G.; Intensive Care Med. 2012 Dec 7. [Epub ahead of print]
PURPOSE: To assess the frequency and contributing factors of medication and dislodgement errors attributable to common routine processes in a cohort of intensive care units, with a special focus on the potential impact of safety climate.

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2012 Dec - Hypertriglyceridemia: a potential side effect of propofol sedation in critical illness

Devaud JC, Berger MM, Pannatier A, Marques-Vidal P, Tappy L, Rodondi N, Chiolero R, Voirol P.; Intensive Care Med. 2012 Dec;38(12):1990-8.
PURPOSE: Hypertriglyceridemia (hyperTG) is common among intensive care unit (ICU) patients, but knowledge about hyperTG risk factors is scarce. The present study aims to identify risk factors favoring its development in patients requiring prolonged ICU treatment.

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2012 Dec - Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign

Casserly B, Gerlach H, Phillips GS, Lemeshow S, Marshall JC, Osborn TM, Levy MM.; Intensive Care Med. 2012 Dec;38(12):1946-54.
OBJECTIVE: The Surviving Sepsis Campaign (SSC) developed guidelines and treatment bundles for the administration of steroids in adult septic shock. However, it is not clear how this has affected clinical practice or patient outcome.

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2012 Dec - Electrical impedance tomography: the holy grail of ventilation and perfusion monitoring? [Review]

Leonhardt S, Lachmann B.; Intensive Care Med. 2012 Dec;38(12):1917-29.
This review summarizes the state-of-the-art in electrical impedance tomography (EIT) for ventilation and perfusion imaging. EIT is a relatively new technology used to image regional impedance distributions in a cross-sectional area of the body...

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2012 Nov - High-dose magnesium sulfate infusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study

Egelund TA, Wassil SK, Edwards EM, Linden S, Irazuzta JE.; Intensive Care Med. 2012 Nov 6. [Epub ahead of print]
PURPOSE: To assess the safety and pharmacokinetics of high-dose magnesium sulfate (MgSO(4)) infusion in pediatric patients with status asthmaticus.

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2012 Sep - Anemia and brain oxygen after severe traumatic brain injury

Oddo M, Levine JM, Kumar M, Iglesias K, Frangos S, Maloney-Wilensky E, Le Roux PD.; Intensive Care Med. 2012 Sep;38(9):1497-504. Epub 2012 May 15.
Purpose: To investigate the relationship between hemoglobin (Hgb) and brain tissue oxygen tension (PbtO2) after severe traumatic brain injury (TBI) and to examine its impact on outcome.

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2012 Sep - Improvement of left ventricular relaxation as assessed by tissue Doppler imaging in fluid-responsive critically ill septic patients

Mahjoub Y, Benoit-Fallet H, Airapetian N, Lorne E, Levrard M, Seydi AA, Amennouche N, Slama M, Dupont H.; Intensive Care Med. 2012 Sep;38(9):1461-70. Epub 2012 Jun 21.
Purpose: Left ventricular (LV) diastolic function is often impaired in critically ill septic patients. The peak velocity of the mitral annulus early wave during diastole (E′), measured by Doppler echocardiography, is a major tool to evaluate LV relaxation, the ATP-dependent part of diastole. The authors hypothesized that if volume expansion (VE) is followed by an increase in stroke volume (SV) (“adequate” VE), LV relaxation and consequently E′ may be increased.

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2012 Sep - Measuring the nursing workload per shift in the ICU

Debergh DP, Myny D, Van Herzeele I, Van Maele G, Reis Miranda D, Colardyn F.; Intensive Care Med. 2012 Sep;38(9):1438-44. Epub 2012 Aug 9.
Purpose: In the intensive care unit (ICU) different strategies and workload measurement tools exist to indicate the number of nurses needed. The gathered information is always focused on manpower needed per 24 h. However, a day consists of several shifts, which may be unequal in nursing workload. The aim of this study was to evaluate if differences in nursing workload between consecutive shifts can be identified by a nursing workload measurement tool.

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2012 Sep - Accuracy of plethysmographic indices as predictors of fluid responsiveness in mechanically ventilated adults: a systematic review and meta-analysis

Sandroni C, Cavallaro F, Marano C, Falcone C, De Santis P, Antonelli M.; Intensive Care Med. 2012 Sep;38(9):1429-37. Epub 2012 Jun 26.
Purpose: To systematically review the accuracy of the variation in pulse oxymetry plethysmographic waveform amplitude (∆POP) and the Pleth Variability Index (PVI) as predictors of fluid responsiveness in mechanically ventilated adults.

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2012 Jul - Causes and risk factors of death in patients with thrombotic microangiopathies.

Peigne V, Perez P, Resche Rigon M, Mariotte E, Canet E, Mira JP, Coppo P, Veyradier A, Azoulay E.; Intensive Care Med. 2012 Jul 14. [Epub ahead of print]
PURPOSE: Although plasma therapy of thrombotic micro-angiopathies (TMAs) has dramatically improved survival, the outcome remains fatal in up to 15 % of patients. We investigated the causes and risk factors of death in patients with TMA.

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2012 Jul - Association between hyperkalemia at critical care initiation and mortality

McMahon GM, Mendu ML, Gibbons FK, Christopher KB.;Intensive Care Med. 2012 Jul 18. [Epub ahead of print]
PURPOSE: To investigate the association between potassium concentration at the initiation of critical care and all-cause mortality.

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