Which of the following is incorrect about C-reactive protein (CRP) in acute phase response?
A. It rises rapidly within 6 to 10 h following the inflammatory event.
B. No hepatic store or tissue concentration exists.
C. Long half-life of approximately 48 h in man.
D. Circulating concentration is determined solely by the its rate of synthesis and hence inflammatory stimulus.
Answer: C
It has a short half-life of approximately 19 h in man, and declines rapidly following the decrease in inflammatory activity.
Reference
Oxford textbook of rheumatology 2nd ed. edition: By by David Isenberg (Editor), et al Oxford University Press.