Filiponi TC, Durão MD Junior.; Shock. 2013 Mar 11. [Epub ahead of print]
Sepsis is the main cause of acute kidney injury (AKI) among individuals hospitalized in intensive care units. AKI is an independent risk factor for mortality, and its occurrence increase the complexity and cost of treatment…
However, the pathophysiological mechanisms of AKI remain unclear. Hemodynamic, vascular, tubular, cellular, inflammatory, and oxidative processes are involved. Individuals suffering from AKI generally have various comorbidities and are elderly, hypercatabolic, and on vasopressors and mechanical ventilation. Dialysis is the main treatment for AKI. Although there is no clear benefit of any specific dialysis modality, these patients are initially instructed to use continuous dialysis methods, especially for the most severe cases with multiple organ system dysfunctions and for those who display signs of hemodynamic instability. Recent studies demonstrate that patients should receive a dialysis dose of at least 25 ml/kg/h.
Weblink here