Sarah Vecchio1 and Alessandro Protti2*. Critical Care 2011, 15:107
Abstract (provisional)
Metformin is a safe drug when correctly used in properly selected patients. However, in real life, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any other major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy.
Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is quite always surprisingly good.
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