Josef Neu, M.D., and W. Allan Walker, M.D. N Engl J Med 2011; 364:255-264January 20, 2011
Necrotizing enterocolitis is among the most common and devastating diseases in neonates. It has also been one of the most difficult to eradicate1 and thus has become a priority for research.2 Conditions closely resembling necrotizing enterocolitis were described before the 1960s, but the entity was not widely recognized until after the advent of modern neonatal intensive care.1
Since that time, the incidence of necrotizing enterocolitis and the associated morbidity and mortality have remained unchanged because of ever-improving survival of the smallest infants; in some instances, these rates have actually increased. On the basis of large, multicenter, neonatal network databases from . . .
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