Richard S. Hotchkiss, M.D., and Steven Opal, M.D. NEJM Volume 363:87-89 July 1, 2010 Number 1
Septic shock is traditionally viewed as an excessive systemic inflammatory reaction to invasive microbial pathogens, yet efforts to improve the outcome of patients with sepsis by means of inhibitors of proinflammatory cytokines and mediators have been unsuccessful.
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