Jerrold H Levy a b. The Lancet, Early Online Publication, 15 June 2010doi:10.1016/S0140-6736(10)60939-7Cite or Link Using DOI
Activation of the fibrinolytic system is an integral part of vascular haemostatic mechanisms to maintain vascular patency. The basis of fibrinolysis is the conversion of the inactive substrate plasminogen to plasmin, an enzyme that cleaves fibrin but also has pleiotropic effects. 1 , 2
Multiple mechanisms are responsible for generating plasmin, including endothelial activation and release of tissue plasminogen activator, and contact activation and kallikrein-mediated plasmin activation. 1—3 Tissue-typ …
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