2009 Nov 11 – NEJM Correspondence: Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis

Mariana Baz, M.Sc., et al; Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada. Published at www.nejm.org November 11, 2009
To the Editor: Neuraminidase inhibitors (oseltamivir and zanamivir) are recommended for treatment of severe illness caused by the 2009 pandemic influenza A (H1N1) virus, and their use has also been advocated for postexposure prophylaxis in high-risk persons.1 We report the emergence of an oseltamivir-resistant virus in a familial cluster of infections with the 2009 H1N1 virus.


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