2012.03.30 Quiz: Posaconazole

Which of the following is incorrect about posaconazole?
A. One of the indications is invasive aspergillosis refractory to amphotericin B or itraconazole
B. No dose adjustment is necessary for renal impairment; for hepatic impairment, no recommendation can be made because of limited pharmacokinetics data.
C. QTc prolongation and torsades de pointes have been reported as side effects
D. Bioavailability is decreased when taken with a meal.
E. Usual dose for invasive aspergillosis of oral suspension is 200mg tds. One report of accidental overdose of 1200mg bd for 3 days did not result in any adverse reactions.