Scott C. Howard, M.D., Deborah P. Jones, M.D., and Ching-Hon Pui, M.D. N Engl J Med 2011; 364:1844-1854, May 12, 2011
The tumor lysis syndrome is the most common disease-related emergency encountered by physicians caring for children or adults with hematologic cancers.14
Although it develops most often in patients with non-Hodgkin’s lymphoma or acute leukemia, its frequency is increasing among patients who have tumors that used to be only rarely associated with this complication.58 The tumor lysis syndrome occurs when tumor cells release their contents into the bloodstream, either spontaneously or in response to therapy, leading to the characteristic findings of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia.13 These electrolyte and metabolic disturbances can progress to clinical toxic effects, including . . .
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