Answer: D
A. Ertapenem is not active vs Pseudomonas, and also not active ampicillin-resistant enterococci, pseudomonas and Acinetobacter
B. Cilastatin is for the prevention of degradation of imipenem by the renal enzyme dehydropeptidase 1
C. Doripenem is effective vs Pseudomonas aeruginosa
D. Ertapenem is given one gram once a day, therefore very convenient, but it is not active against Pseudomonas.
E. It has been reported that In Brazil, a strain of A. baumannii resistant to imipenem and meropenem due to an OXA-type carbapenemase infected eight patients in two hospitals; five of the patients died, despite therapy with multiple antibiotics (Ref: Jacoby GA, Munoz-Price LS. The New β-Lactamases. N Engl J Med 352:380, January 27, 2005 Review Article — Mechanisms of Disease)