About neuroleptic malignant syndrome (NMS), which of the following is incorrect?
A. a potentially fatal condition characterized by hyperthermia, muscle rigidity, autonomic dysfunction, and mental confusion
B. often associated with rhabdomyolysis and myoglobinuric renal failure
C. it is a variant of the malignant hyperthermia syndrome, and responds to early treatment with the muscle relaxant dantrolene
D. chance of NMS is higher if a higher haloperidol dosage is used for a longer duration
Answer: D
NMS is an idiosyncratic response to haloperidol and is independent of drug dosage or duration of therapy (58). Early recognition is mandatory for successful treatment with dantrolene.
Reference
Paul L. Marino. THE ICU BOOK (Second Edition)