About the clinical and mycologic characteristics of the most common invasive molds in hematologic cancers, which of the following is incorrect?
A. Aspergillus species: blood cultures often not positive, non-culture based methods (tests for galactomannan and 1.3-beta-D-glucan) may facilitate diagnosis
B. Fusarium species: skin lesions characteristically erythematous and nodular, may have a necrotic center
C. Zygomycetes: preferred therapy is high dose liposomal amphotericin B or posaconazole
D. Scedosporium species: associated with near-drowning, resistant to amphotericin B
E. Phaeohyphomycosis: resistant to all anti-fungals
Answer: E
Preferred therapy for Phaeohyphomycosis is with new azoles and polyene.
Reference
1. Thomas F. Patterson, M.D., Bonnie T. Mackool, M.D., Matthew D. Gilman, M.D., and Adriano Piris, M.D.Case 22-2009 — A 59-Year-Old Man with Skin and Pulmonary Lesions after Bone Marrow Transplantation. NEJM, Volume 361:287-296 July 16, 2009 Number 3
2. An Atlas of the Clinical Microbiology of Infectious Diseases: Viral, fungal … 作者：Edward J. Bottone