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2009.06.25 Quiz: Polymyositis- and Dermatomyositis-associated Interstitial Lung Disease

Which of the following is not commonlay associated with polymyositis and dermatomyositis?
A. bronchiolitis obliterans with organizing pneumonia (BOOP; or cryptogenic organizing pneumonia)
B. diffuse panbronchiolitis
C. nonspecific interstitial pneumonia (NSIP)
D. usual interstitial pneumonia (UIP)
E. diffuse alveolar damage (DAD)

Answer: B. Diffuse panbronchiolitis

Diffuse panbronchiolitis (DPB) is a progressive inflammatory disease, well recognized in Japan, characterized by sinusitis and obstructive small airway disease; if left untreated, it progresses to bronchiectasis, respiratory failure, and death. Treatment using low-dose erythromycin has proven to be highly efficacious.

References
1. Medscape
2. WILLIAM W. DOUGLAS, HENRY D. TAZELAAR, THOMAS E. HARTMAN, ROBERT P. HARTMAN, PAUL A. DECKER, DARRELL R. SCHROEDER, and JAY H. RYU Polymyositis-Dermatomyositis-associated Interstitial Lung Disease. Am. J. Respir. Crit. Care Med., Volume 164, Number 7, October 2001, 1182-1185
3. S C Poh, Y T Wang, W Y Wang. Diffuse Panbronchiolitis – A Case Report. Singapore Med J 2001 Vol 42(6) : 271-274
4. Kenneth W T Tsang,a Clara G C Ooi,b Mary S M Ip,a Wah-kit Lam,a Henry Ngan,b Eric Y T Chan,c Brian Hawkins,c Chu-shak Ho,a Ryoichi Amitani,d Eisaku Tanaka,d Harumi Itohd. Clinical profiles of Chinese patients with diffuse panbronchiolitis. Thorax 1998;53:274-280 ( April ). Thorax 1998;53:274-280; doi:10.1136/thx.53.4.274 
5. Padmanabhan Krishnan, MBBS, FCCP, Rajeeve Thachil, MBBS, and Virgilio Gillego, MD. Diffuse Panbronchiolitis*. A Treatable Sinobronchial Disease in Need of Recognition in the United States. CHEST February 2002 vol. 121 no. 2 659-661