2009 Sep – Case Report: H1N1 pneumonitis treated with intravenous zanamivir

Dr I Michael Kidd FRCPath a , Jim Down FRCA b, Eleni Nastouli FRCPath a, Rob Shulman DHCPharm b, Paul R Grant PhD a, David CJ Howell MRCP b, Mervyn Singer FRCP bThe Lancet, Early Online Publication, 4 September 2009

Figure (click image to enlarge): IV preparation of Zanamivir. Previous studies have also used this preparation for trial for nebulization. This preparation is not yet registered in Hong Kong.
On July 8, 2009, a 22-year-old woman, neutropenic after chemotherapy for Hodgkin’s disease, was referred to ICU with 3 days’ (d) increasing dyspnoea, bilateral chest infiltrates, and laboratory-confirmed pandemic H1N1 2009 influenza virus infection not responding to oseltamivir 75 mg twice daily and broad-spectrum antimicrobials (meropenem, teicoplanin, and caspofungin). No other organisms were detected from blood or respiratory tract. Deterioration necessitated invasive ventilation from ICU d 3 (figure).

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