Ait-Oufella H, Bige N, Boelle PY, Pichereau C, Alves M, Bertinchamp R, Baudel JL, Galbois A, Maury E, Guidet B.; Intensive Care Med. 2014 Jul;40(7):958-64
BACKGROUND: During septic shock management, the evaluation of microvascular perfusion by skin analysis is of interest. We aimed to study the skin capillary refill time (CRT) in a selected septic shock population.
2014 Jul - Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen
de Montmollin E, Bouadma L, Gault N, Mourvillier B, Mariotte E, Chemam S, Massias L, Papy E, Tubach F, Wolff M, Sonneville R.: Intensive Care Med. 2014 Jul;40(7):998-1005.
PURPOSE: Amikacin requires pharmacodynamic targets of peak serum concentration (C max) of 8-10 times the minimal inhibitory concentration, corresponding to a target C max of 60-80 mg/L for the less susceptible bacteria. Even with new dosing regimens of 25 mg/kg, 30 % of patients do not meet the pharmacodynamic target. We aimed to identify predictive factors for insufficient C max in a population of critically ill patients.
Date: 24 Jul 2014; Time: 18:30 - 20:15; Venue: Senior Police Officers Mess, Police HQ, Arsenal Street
Speaker: Dr Peter Au-Yeung
Pierrakos C, Velissaris D, Franchi F, Muzzi L, Karanikolas M, Scolletta S. J Clin Med Res. 2014 Apr;6(2):75-85.
Levosimendan, the active enantiomer of simendan, is a calcium sensitizer developed for treatment of decompensated heart failure, exerts its effects independently of the beta adrenergic receptor and seems beneficial in cases of severe, intractable heart failure...
2014 Apr - Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion
Esper SA, Levy JH, Waters JH, Welsby IJ. Anesth Analg. 2014 Apr;118(4):731-43.
Extracorporeal membrane oxygenation (ECMO) is a method of life support to maintain cardiopulmonary function. Its use as a medical application has increased since its inception to treat multiple conditions including acute respiratory distress syndrome, myocardial ischemia, cardiomyopathy, and septic shock. While complications including neurological and renal injury occur in patients on ECMO, bleeding and coagulopathy are most common...
2014 Aug - Myocardial depression in sepsis: From pathogenesis to clinical manifestations and treatment
Antonucci E, Fiaccadori E, Donadello K, Taccone FS, Franchi F, Scolletta S. J Crit Care. 2014 Aug;29(4):500-511.
The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a common finding associated with increased morbidity and mortality. Myocardial depression during sepsis is not clearly defined, but it can perhaps be best described as a global (systolic and diastolic) dysfunction of both the left and right sides of the heart...
Date: 22/7/2014: Time: 6:30-8:30pm; Venue: Lecture Theatre, M block, G/F, QEH
Di Rosa R, Pietrosanti M, Luzi G, Salemi S, D'Amelio R. Eur J Intern Med. 2014 Jul;25(6):511-516.
Sepsis syndrome is characterized by a systemic inflammatory response to infection potentially leading to acute organ failure and rapid decline to death. Polyclonal intravenous immune globulin, a blood product derived from human donor blood, in addition to antiinfective activities, also exerts a broad antiinflammatory and immunomodulating effect. Intravenous immunoglobulin (IVIg) has been proposed as adjuvant therapy for sepsis even though the clinical studies demonstrating their efficacy and safety are relatively small...
Rostami E. Front Neurol. 2014 Jun 6;5:91.
Cerebral microdialysis (CMD) is a laboratory tool that provides on-line analysis of brain biochemistry via a thin, fenestrated, double-lumen dialysis catheter that is inserted into the interstitium of the brain. A solute is slowly infused into the catheter at a constant velocity...
Zeiler FA, Teitelbaum J, West M, Gillman LM. Neurocrit Care. 2014 Feb 11.
Our goal was to perform a systematic review of the literature on the use of ketamine in traumatic brain injury (TBI) and its effects on intracranial pressure (ICP).
2014 Jul - A comparison of different diagnostic criteria of acute kidney injury in critically ill patients
Xuying Luo, Li Jiang, Bin Du, Ying Wen, Meiping Wang, Xiuming Xi; Critical Care 2014, 18:R144 (8 July 2014)
Introduction: Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) proposed a new definition and classification of acute kidney injury (AKI) based on the RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage renal failure) and AKIN (Acute Kidney Injury Network) criteria but the comparison of three criteria in critically ill patients is rare.
2014 Jul - Chlorhexidine-Impregnated Dressing for Prevention of Catheter-Related Bloodstream Infection: A Meta-Analysis
Safdar N, O'Horo JC, Ghufran A, Bearden A, Didier ME, Chateau D, Maki DG. Crit Care Med. 2014 Jul;42(7):1703-13.
Objective: To assess the efficacy of a chlorhexidine-impregnated dressing for prevention of central venous catheter–related colonization and catheter-related bloodstream infection using meta-analysis.
2014 Jul - A Comparison of Severe Hemodynamic Disturbances Between Dexmedetomidine and Propofol for Sedation in Neurocritical Care Patients
Erdman MJ, Doepker BA, Gerlach AT, Phillips GS, Elijovich L, Jones GM. Crit Care Med. 2014 Jul;42(7):1696-702.
Objective: Dexmedetomidine and propofol are commonly used sedatives in neurocritical care as they allow for frequent neurologic examinations. However, both agents are associated with significant hemodynamic side effects. The primary objective of this study is to compare the prevalence of severe hemodynamic effects in neurocritical care patients receiving dexmedetomidine and propofol.
2014 Jul - Early Administration of Hydrocortisone Replacement After the Advent of Septic Shock: Impact on Survival and Immune Response
Katsenos CS, Antonopoulou AN, Apostolidou EN, Ioakeimidou A, Kalpakou GT, Papanikolaou MN, Pistiki AC, Mpalla MC, Paraschos MD, Patrani MA, Pratikaki ME, Retsas TA, Savva AA, Vassiliagkou SD, Lekkou AA, Dimopoulou I, Routsi C, Mandragos KE; Hellenic Sepsis Study Group. Crit Care Med. 2014 Jul;42(7):1651-7.
Objectives: To investigate the impact of early initiation of hydrocortisone therapy on the clinical course of septic shock and on cytokine release.
2014 Jul - Ventilator-Associated Pneumonia During Weaning From Mechanical Ventilation: Role of Fluid Management
Armand Mekontso Dessap, MD, PhD; Sandrine Katsahian, MD; Ferran Roche-Campo, MD, PhD; Hugo Varet, PhD; Achille Kouatchet, MD; Vinko Tomicic, MD; Gaetan Beduneau, MD; Romain Sonneville, MD, PhD; Samir Jaber, MD, PhD; Michael Darmon, MD, PhD; Diego Castanares-Zapatero, MD; Laurent Brochard, MD; Christian Brun-Buisson, MD CHEST Jul 2014; 146(1): 58-65
BACKGROUND: Pulmonary edema may alter alveolar bacterial clearance and infectivity. Manipulation of fluid balance aimed at reducing fluid overload may, therefore, influence ventilator-associated pneumonia (VAP) occurrence in intubated patients. The objective of the present study was to assess the impact of a depletive fluid-management strategy on ventilator-associated complication (VAC) and VAP occurrence during weaning from mechanical ventilation.
Craig M. Lilly, MD, FCCP; Xinggang Liu, MD, PhD; Omar Badawi, PharmD, MPH; Christine S. Franey, MPH; Ilene H. Zuckerman, PharmD, PhD CHEST Jul 2014; 146(1): 51-57
BACKGROUND: The optimal approach for managing increased risk of VTE among critically ill adults is unknown.
2014 Jul 1 - Oxygenation Response to Positive End-Expiratory Pressure Predicts Mortality in Acute Respiratory Distress Syndrome. A Secondary Analysis of the LOVS and ExPress Trials
Ewan C. Goligher, Brian P. Kavanagh, Gordon D. Rubenfeld, Neill K. J. Adhikari, Ruxandra Pinto, Eddy Fan, Laurent J. Brochard, John T. Granton, Alain Mercat, Jean-Christophe Marie Richard, Jean-Marie Chretien, Graham L. Jones, Deborah J. Cook, Thomas E. Stewart, Arthur S. Slutsky, Maureen O. Meade, and Niall D. Ferguson Am. J. Resp. Crit. Care Med. Vol. Jul 1, 2014, vol. 190, no. 1: pp. 70-76
Rationale: Previous trials of higher positive end-expiratory pressure (PEEP) for acute respiratory distress syndrome (ARDS) failed to demonstrate mortality benefit, possibly because of differences in lung recruitability among patients with ARDS.
Hallie C. Prescott, Kenneth M. Langa, Vincent Liu, Gabriel J. Escobar, and Theodore J. Iwashyna Am. J. Resp. Crit. Care Med. Jul 1, 2014, vol. 190, no. 1: 62-69
Rationale: Hospitalizations for severe sepsis are common, and a growing number of patients survive to hospital discharge. Nonetheless, little is known about survivors’ post-discharge healthcare use.
Date: 15 Nov 2014
Message from the organizer
We are pleased to advise you that the Health Research Symposium 2014 organised by the Food and Health Bureau, the Government of the Hong Kong Special Administrative Region, will be held on 15 November 2014 at the Hong Kong Academy of Medicine. The theme of the Symposium is Translating Health Research into Policy and Practice for Health of the Population. Please post the following event information on your website for the interest of your members:
2014 Jul - The Impact of Variation in Renal Replacement Therapy Settings on Piperacillin, Meropenem, and Vancomycin Drug Clearance in the Critically Ill: An Analysis of Published Literature and Dosing Regimens
Jamal JA, Udy AA, Lipman J, Roberts JA. Crit Care Med. 2014 Jul;42(7):1640-50.
Objectives: To describe the effect of different renal replacement therapy modalities and settings on the clearance of meropenem, piperacillin, and vancomycin in critically ill patients and to evaluate the frequency with which current dosing regimens achieve therapeutic concentrations.