2016 Dec - Prophylactic versus clinically-driven antibiotics in comatose survivors of out-of-hospital cardiac arrest—A randomized pilot study
Ribaric SF, Turel M, Knafelj R, Gorjup V, Stanic R, Gradisek P, Cerovic O, Mirkovic T, Noc M.; Resuscitation. 2017 Feb;111:103-109.
AIM: To investigate benefits of prophylactic antibiotics in comatose survivors of out-of-hospital cardiac arrest (OHCA).
METHODS: Patients without evidence of tracheobronchial aspiration on admission bronchoscopy were randomized to prophylactic Amoxicillin-Clavulanic acid 1.2g every 8h (P) or clinically-driven antibiotics (C) administered if signs of infection developed during initial 7days of intensive care unit (ICU) stay.
Gilhus NE.; N Engl J Med. 2016 Dec 29;375(26):2570-2581.
Myasthenia gravis is an autoimmune disease associated with several autoantibodies that attack the neuromuscular junction. Some cases are associated with thymoma. The hallmark of management is individualized immunosuppressive therapy.
Date: 13-14 May 2017; Venue: Room N101, 1/ F New Wing, HKCEC
Legriel S, Lemiale V, Schenck M, Chelly J, Laurent V, Daviaud F, Srairi M, Hamdi A, Geri G, Rossignol T, Hilly-Ginoux J, Boisramé-Helms J, Louart B, Malissin I, Mongardon N, Planquette B, Thirion M, Merceron S, Canet E, Pico F, Tran-Dinh YR, Bedos JP, Azoulay E, Resche-Rigon M, Cariou A; HYBERNATUS Study Group..; N Engl J Med. 2016 Dec 22;375(25):2457-2467.
Background: Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus.
2017 Jan - Effect of Procalcitonin Testing on Health-care Utilization and Costs in Critically Ill Patients in the United States
Robert A. Balk, MD; Sameer S. Kadri, MD; Zhun Cao, PhD; Scott B. Robinson, MA, MPH; Craig Lipkin, MS; Samuel A. Bozzette, MD, PhD CHEST Jan 2017; 151(1): 23-3
Background: There is a growing use of procalcitonin (PCT) to facilitate the diagnosis and management of severe sepsis. We investigated the impact of one to two PCT determinations on ICU day 1 on health-care utilization and cost in a large research database.
Yonatan Y. Greenstein, MD; Ross Littauer, MD; Mangala Narasimhan, DO, FCCP; Paul H. Mayo, MD, FCCP; Seth J. Koenig, MD, FCCP CHEST Jan, 2017; 151(1): 34-40
Background: Widespread use of critical care ultrasonography (CCUS) for the management of patients in the ICU requires an effective training program. The effectiveness of national and regional CCUS training courses is not known. This study describes a national-level, simulation-based, 3-day CCUS training program and evaluates its effectiveness.
Eric L. Scholten, MD; Jeremy R. Beitler, MD, MPH; G. Kim Prisk, PhD, DSc; Atul Malhotra, MD CHEST Jan, 2017; 151(1): 215-224
Prone positioning was first proposed in the 1970s as a method to improve gas exchange in ARDS. Subsequent observations of dramatic improvement in oxygenation with simple patient rotation motivated the next several decades of research.
2017 Jan - The effects of performance status one week before hospital admission on the outcomes of critically ill patients
Zampieri FG, Bozza FA, Moralez GM, Mazza DD, Scotti AV, Santino MS, Ribeiro RA, Rodrigues Filho EM, Cabral MM, Maia MO, D'Alessandro PS, Oliveira SV, Menezes MA, Caser EB, Lannes RS, Alencar Neto MS, Machado MM, Sousa MF, Salluh JI, Soares M.; Intensive Care Med. 2017 Jan;43(1):39-47.
Purpose: To assess the impact of performance status (PS) impairment 1 week before hospital admission on the outcomes in patients admitted to intensive care units (ICU).
Martin-Loeches I, J Schultz M, Vincent JL, Alvarez-Lerma F, Bos LD, Solé-Violán J, Torres A, Rodriguez A.; Intensive Care Med. 2017 Jan;43(1):48-58.
Background: Co-infection is frequently seen in critically ill patients with influenza, although the exact rate is unknown. We determined the rate of co-infection, the risk factors and the outcomes associated with co-infection in critically ill patients with influenza over a 7-year period in 148 Spanish intensive care units (ICUs).
Date: 16 Jan 2017 (MONDAY); Time: 6:30 - 8:30pm, Venue: Lecture theatre, G/F, M Block, QEH
2017 Jan - Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials
Yamada T, Shojima N, Noma H, Yamauchi T, Kadowaki T.; Intensive Care Med. 2017 Jan;43(1):1-15.
Purpose: It is unclear whether tight glycemic control is warranted in all critically ill adults. We employed network meta-analysis to examine the risk of mortality and hypoglycemia associated with different glycemic control targets in critically ill adults.
2017 Jan 1 - Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study
Giacomo Bellani, John G. Laffey, Tài Pham, Fabiana Madotto, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Vesna Bumbasirevic, Lise Piquilloud, Frank van Haren, Anders Larsson, Daniel F. McAuley, Philippe R. Bauer, Yaseen M. Arabi, Marco Ranieri, Massimo Antonelli, Gordon D. Rubenfeld, B. Taylor Thompson, Hermann Wrigge, Arthur S. Slutsky, Antonio Pesenti, on behalf of the LUNG SAFE Investigatorsthe ESICM Trials Group Am. J. Resp. Crit. Care Med. vol. 195, no. 1: 67-77
Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse.
2017 Jan 1 - Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation from Mechanical Ventilation in Medical Intensive Care Unit Patients
Martin Dres, Bruno-Pierre Dubé, Julien Mayaux, Julie Delemazure, Danielle Reuter, Laurent Brochard, Thomas Similowski, Alexandre Demoule Am. J. Resp. Crit. Care Med. Jan 1, 2017, vol. 195, no. 1: 57-66
Rationale: Intensive care unit (ICU)- and mechanical ventilation (MV)-acquired limb muscle and diaphragm dysfunction may both be associated with longer length of stay and worse outcome. Whether they are two aspects of the same entity or have a different prevalence and prognostic impact remains unclear.
Meersch M, Zarbock A.; Curr Opin Crit Care. 2016 Dec;22(6):554-559.
Purpose of review: Among critically ill patients, acute kidney injury (AKI) is still a common and serious complication with a tremendous impact on short-term and long-term outcomes. The objective of this review is to discuss strategies for renal protection and prevention of AKI in ICU patients.
2016 Dec - Association between time of discharge from ICU and hospital mortality: a systematic review and meta-analysis
Yang S, Wang Z, Liu Z, Wang J, Ma L. Crit Care. 2016 Dec 1;20(1):390.
BACKGROUND: Epidemiological studies have provided inconsistent results on whether intensive care unit (ICU) discharge at night and on weekends is associated with an increased risk of mortality. This systematic review and meta-analysis aimed to determine whether ICU discharge time was associated with hospital mortality.
2016 Oct - Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery
Duceppe E, Parlow J, MacDonald P, Lyons K, McMullen M, Srinathan S, Graham M, Tandon V, Styles K, Bessissow A, Sessler DI, Bryson G, Devereaux PJ.; Can J Cardiol. 2016 Oct 4.
The Canadian Cardiovascular Society Guidelines Committee and key Canadian opinion leaders believed there was a need for up to date guidelines that used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system of evidence assessment for patients who undergo noncardiac surgery.
Date: 2 Dec 2016; Venue: PYNEH ICU; Speaker: Dr Alex TY Li
2016 Dec - Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials
Putzu A, Capelli B, Belletti A, Cassina T, Ferrari E, Gallo M, Casso G, Landoni G.; Crit Care. 2016 Dec 5;20(1):395.
BACKGROUND: Several studies suggest beneficial effects of perioperative statin therapy on postoperative outcome after cardiac surgery. However, recent randomized controlled trials (RCTs) show potential detrimental effects. The objective of this systematic review is to examine the association between perioperative statin therapy and clinical outcomes in cardiac surgery patients.
Veltkamp R, Gill D.; Neurotherapeutics. 2016 Oct;13(4):791-800
Inflammatory mechanisms are currently considered as a prime target for stroke therapy. There is evidence from animal studies that immune signals and mediators can have both detrimental and beneficial effects in particular stages of the disease process. Moreover, several of these mechanisms are turned on with sufficient delay after ischemia onset to make them amenable to therapeutic intervention. Several clinical proof-of concept trials have investigated the efficacy of different immunomodulatory approaches in patients with stroke.