2015 Jul - Comparative Effectiveness of Noninvasive and Invasive Ventilation in Critically Ill Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Stefan MS, Nathanson BH, Higgins TL, Steingrub JS, Lagu T, Rothberg MB, Lindenauer PK.; Crit Care Med. 2015 Jul;43(7):1386-94.
Objectives: To compare the characteristics and hospital outcomes of patients with an acute exacerbation of chronic obstructive pulmonary disease treated in the ICU with initial noninvasive ventilation or invasive mechanical ventilation.
2015 Jul - Effects and Clinical Characteristics of Intracranial Pressure Monitoring–Targeted Management for Subsets of Traumatic Brain Injury: An Observational Multicenter Study
Yuan Q, Wu X, Yu J, Sun Y, Li Z, Du Z, Mao Y, Zhou L, Hu J.; Crit Care Med. 2015 Jul;43(7):1405-14.
Objectives: To evaluate the efficacy of traumatic brain injury management guided by intracranial pressure monitoring and to explore the specific subgroups for which intracranial pressure monitoring might be significantly associated with improved outcomes based on a classification of the various traumatic brain injury pathophysiologies using the clinical features and CT scans.
Heyland D, Cook D, Bagshaw SM, Garland A, Stelfox HT, Mehta S, Dodek P, Kutsogiannis J, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network.; Crit Care Med. 2015 Jul;43(7):1352-60.
Objective: Very elderly persons admitted to ICUs are at high risk of death. To document life-sustaining interventions (mechanical ventilation, vasopressors, renal replacement therapy) provided in the ICU and outcomes of care.
Wong AK, Walkey AJ. Ann Am Thorac Soc. 2015 Jun 11. [Epub ahead of print]
RATIONALE: Open lung biopsy may be performed to guide therapy in mechanically ventilated patients with diagnostic uncertainty regarding etiology of pulmonary infiltrates. Current evidence for open lung biopsy in mechanically ventilated patients comes from single center case series.OBJECTIVES: We performed a meta-analysis of case series to determine diagnoses, complications, and changes in therapy following lung biopsy in critically ill patients requiring mechanical ventilation.
2015 Jun -Endotracheal intubation versus supraglottic airway placement in out-of-hospital cardiac arrest: A meta-analysis
Benoit JL, Gerecht RB, Steuerwald MT, McMullan JT.; Resuscitation. 2015 May 23;93:20-26.
OBJECTIVE: Overall survival from out-of-hospital cardiac arrest (OHCA) is less than 10%. After initial bag-valve mask ventilation, 80% of patients receive an advanced airway, either by endotracheal intubation (ETI) or placement of a supraglottic airway (SGA). The objective of this meta-analysis was to compare patient outcomes for these two advanced airway methods in OHCA patients treated by Emergency Medical Services (EMS).
Ritesh Maharaj, Ivan Raffaele, Julia Wendon Critical Care 2015, 19:254 (12 June 2015)
Introduction: Although rapid response system teams have been widely adopted by many health systems, their effectiveness in reducing hospital mortality is uncertain. We conducted a meta-analysis to examine the impact of rapid response teams on hospital mortality and cardiopulmonary arrest.
Mouhamed Moussa, Sabino Scolletta, David Fagnoul, Pierre Pasquier, Alexandre Brasseur, Fabio Taccone, Jean-Louis Vincent, Daniel De Backer Critical Care 2015, 19:250 (12 June 2015)
Introduction: Fluid administration is a first-line therapy for acute kidney injury associated with circulatory failure. Although aimed at increasing renal perfusion in these patients, this intervention may improve systemic hemodynamics without necessarily ameliorating intra-renal flow distribution or urine output. We used Doppler techniques to investigate the effects of fluid administration on intra-renal hemodynamics and the relationship between changes in renal hemodynamics and urine output. We hypothesized that, compared to systemic hemodynamic variables, changes in renal hemodynamics would better predict increase in urine output after fluid therapy.
Matthew Rowan, Leopoldo Cancio, Eric Elster, David Burmeister, Lloyd Rose, Shanmugasundaram Natesan, Rodney Chan, Robert Christy, Kevin Chung Critical Care 2015, 19:243 (12 June 2015)
Burns are a prevalent and burdensome critical care problem. The priorities of specialized facilities focus on stabilizing the patient, preventing infection, and optimizing functional recovery. Research on burns has generated sustained interest over the past few decades, and several important advancements have resulted in more effective patient stabilization and decreased mortality, especially among young patients and those with burns of intermediate extent.
2015 Jun - A randomized controlled trial on the effects of goal directed therapy on the inflammatory response open abdominal aortic aneurysm repair
Funk DJ, HayGlass KT, Koulack J, Harding G, Boyd A, Brinkman R.; Crit Care. 2015 Jun 10;19(1):247. [Epub ahead of print]
INTRODUCTION: Goal directed therapy (GDT) has been shown in numerous studies to decrease perioperative morbidity and morality. The mechanism of benefit of GDT however, has not been clearly elucidated. Targeted resuscitation of the vascular endothelium with GDT might alter the postoperative inflammatory response and be responsible for the decreased complications with this therapy.
2015 May - How can we ensure effective antibiotic dosing in critically ill patients receiving different types of renal replacement therapy?
Jamal JA, Mueller BA, Choi GY, Lipman J, Roberts JA.; Diagn Microbiol Infect Dis. 2015 May;82(1):92-103.
Determining appropriate antibiotic dosing for critically ill patients receiving renal replacement therapy (RRT) is complex. Worldwide unstandardized and heterogeneous prescribing of RRT as well as altered patient physiology and pathogen susceptibility all cause drug disposition to be much different to that seen in non-critically ill patients.
Date: 16/6/2015; Time: 6-8pm; Venue: Seminar Room, Block A, QEH; Speaker: Dr Rock Leung
Date: 16/6/2015; Time: 7-8pm; Venue: Seminar Room, Block A, QEH; Speaker: Dr Sandy Ho
Frédérique Schortgen and Pierre Asfar Am. J. Resp. Crit. Care Med. Jun 1, 2015; vol. 191, no. 11: 1226-1231
Sepsis and acute kidney injury (AKI) represent an important burden in intensive care unit clinical practices. The Journal published important contributions in sepsis for novel therapeutic approaches suggesting that combined molecular targets (e.g., dual inhibition of IL-1β and IL-18, and coadministration of endothelial progenitor cells and stromal cell–derived factor-1α analog) could perform better. The clinical effectiveness of 1,25-dihydroxyvitamin D was reported in a double-blind, randomized, placebo-controlled trial.
2015 Jun - Distinct Molecular Phenotypes of Direct vs Indirect ARDS in Single-Center and Multicenter Studies
Carolyn S. Calfee, MD, MAS; David R. Janz, MD; Gordon R. Bernard, MD, FCCP; Addison K. May, MD; Kirsten N. Kangelaris, MD, MAS; Michael A. Matthay, MD, FCCP; Lorraine B. Ware, MD, FCCP; the NIH NHLBI ARDS Network CHEST Jun 2015; 147(6): 1539-1548
BACKGROUND: ARDS is a heterogeneous syndrome that encompasses lung injury from both direct and indirect sources. Direct ARDS (pneumonia, aspiration) has been hypothesized to cause more severe lung epithelial injury than indirect ARDS (eg, nonpulmonary sepsis); however, this hypothesis has not been well studied in humans.
2015 Jun - Impact of COPD in the Outcome of ICU-Acquired Pneumonia With and Without Previous Intubation
Mariano Rinaudo, MD; Miquel Ferrer, MD, PhD; Silvia Terraneo, MD; Francesca De Rosa, MD; Rogelio Peralta, MD; Laia Fernández-Barat, PhD; Gianluigi Li Bassi, MD, PhD; Antoni Torres, MD, PhD CHEST Jun 2015; 147(6): 1530-1538
BACKGROUND: COPD seems related to poor outcome in patients with ventilator-associated pneumonia (VAP). However, many patients in the ICU with COPD do not require intubation but can also develop pneumonia in the ICU. We, therefore, compared the characteristics and outcomes of patients with ICU-acquired pneumonia (ICUAP) with and without underlying COPD.
2015 Jun - Comparison of a Self-Inflating Bulb Syringe and a Colorimetric CO2 Indicator With Capnography and Radiography to Detect the Misdirection of Naso/Orogastric Tubes Into the Airway of Critically Ill Adult Patients
Nicholas A. Smyrnios, MD, FCCP; Richard Lenard, RRT-NPS, RPFT; Sunil Rajan, MD, FCCP; Michael S. Newman, DO; Stephen P. Baker, MScPH; Nehal Thakkar, MD, FCCP; Wahid Wassef, MD; Niraj K. Ajmere, MD; Richard S. Irwin, MD, Master FCCP CHEST Jun 2015; 147(6): 1523-1529
OBJECTIVE: The objective of this study was to develop a mechanism of discovering misdirection into the airway of naso/orogastric (NG) tubes before they reach their full depth of placement in adults.
2015 Jun - The Use of Inhaled Prostaglandins in Patients With ARDS: A Systematic Review and Meta-analysis
Brian M. Fuller, MD, MSCI; Nicholas M. Mohr, MD; Lee Skrupky, PharmD, BCPS; Susan Fowler, MLIS; Marin H. Kollef, MD, FCCP; Christopher R. Carpenter, MD CHEST Jun 2015; 147(6): 1510-1522
OBJECTIVE: This study aimed to determine whether inhaled prostaglandins are associated with improvement in pulmonary physiology or mortality in patients with ARDS and assess adverse effects.
Dear HKSCCM Members,
To update you our progress, the Critical Care Respiratory Medicine Handbook Editorial Board has been formed.