Date: 15 Apr 2014; Time: 6-7pm, Venue: Seminar Room, Block A, QEH
Speaker: Dr Gary Au
Simard JM, Sheth KN, Kimberly WT, Stern BJ, Del Zoppo GJ, Jacobson S, Gerzanich V.; Neurocrit Care. 2014 Apr;20(2):319-33
The sulfonylurea receptor 1 (Sur1)-transient receptor potential 4 (Trpm4) channel is an important molecular element in focal cerebral ischemia. The channel is upregulated in all cells of the neurovascular unit following ischemia, and is linked to microvascular dysfunction that manifests as edema formation and secondary hemorrhage, which cause brain swelling...
2014 Apr -Human albumin administration in subarachnoid hemorrhage: results of an international survey
Suarez JI, Martin RH, Calvillo E, Zygun D, Flower O, Wong GK, Bershad EM, Venkatasubba Rao CP, Georgiadis A, Jichici D, Leroux PD.;Neurocrit Care. 2014 Apr;20(2):277-86.
BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating disease. Nimodipine is the only medical treatment shown to improve outcome of SAH patients. Human albumin (ALB) may exert neuroprotection in SAH. However, current usage of ALB in SAH is not known. We conducted an international survey of clinicians involved in the care of SAH patients to determine current practice of ALB administration in SAH.
2014 Apr - Therapeutic hypothermia reduces middle cerebral artery flow velocity in patients with severe aneurysmal subarachnoid hemorrhage
Seule M, Muroi C, Sikorski C, Hugelshofer M, Winkler K, Keller E.; Neurocrit Care. 2014 Apr;20(2):255-62.
BACKGROUND: Transcranial Doppler (TCD) is widely used to detect and follow up cerebral vasospasm after subarachnoid hemorrhage (SAH). Therapeutic hypothermia might influence blood flow velocities assessed by TCD. The aim of the study was to evaluate the effect of hypothermia on Doppler blood flow velocity after SAH.
2014 Apr - Adjuvant selenium supplementation in the form of sodium selenite in postoperative critically ill patients with severe sepsis
Yasser Sakr, Vivian PL Maia, Clesar Santos, Julia Stracke, Mohamed Zeidan, Ole Bayer, Konrad Reinhart Critical Care 2014, 18:R68 (9 April 2014)
Introduction: Plasma selenium (Se) concentrations are reduced in critically ill surgical patients and lower plasma Se concentrations are associated with worse outcomes. We investigated whether adjuvant Se supplementation in the form of sodium selenite could improve outcomes in surgical patients with sepsis.
2014 Apr - The Use of Regional Citrate Anticoagulation Continuous Venovenous Haemofiltration in Extracorporeal Membrane Oxygenation
Shum HP, Ming-Chit Kwan A, Chan KC, Yan WW.; ASAIO J. 2014 Apr 10. [Epub ahead of print]
Patients on extracorporeal membrane oxygenation (ECMO) frequently requires continuous renal replacement therapy (CRRT). Additional anticoagulation for the CRRT circuit is usually not employed, but this may increases the risk of clot embolisation, which shortens oxygenator lifespan and increases patient's risk. We report our experience on the use of regional citrate anticoagulation continuous venovenous haemofiltration (RCA-CVVH) connected to an ECMO circuit, which could be useful during low heparin / heparin-free ECMO situations.
2014 Apr - Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies
You-Dong Wan, Tong-Wen Sun, Quan-Cheng Kan, Fang-Xia Guan, Shu-Guang Zhang Critical Care 2014, 18:R71 (11 April 2014)
Introduction: Observational data have suggested that statin therapy may reduce mortality in patients with infection and sepsis; however, results from randomized studies are contradictory and do not support the use of statins in this context. Here, we performed a meta-analysis to investigate the effects of statin therapy on mortality from infection and sepsis.
2014 Apr - Continuous venovenous hemofiltration versus extended daily hemofiltration in patients with septic acute kidney injury: a retrospective cohort study
Zhiping Sun, Hong Ye, Xia Shen, Hongdi Chao, Xiaochun Wu, Junwei Yang Critical Care 2014, 18:R70 (9 April 2014)
Introduction: Whether continuous venovenous hemofiltration (CVVHF) is superior to extended daily hemofiltration (EDHF) for the treatment of septic AKI is unknown. We compared the effect of CVVHF (greater than 72 hours) with EDHF (8 to 12 hours daily) on renal recovery and mortality in patients with severe sepsis or septic shock and concurrent acute kidney injury (AKI).
2014 Apr 15 - Electronic Implementation of a Novel Surveillance Paradigm for Ventilator-associated Events. Feasibility and Validation
Peter M. C. Klein Klouwenberg, Maaike S. M. van Mourik, David S. Y. Ong, Janneke Horn, Marcus J. Schultz, Olaf L. Cremer, and Marc J. M. Bonten Am. J. Resp. Crit. Care Med. Apr 15, 2014, vol. 189, no. 8: 947-955
Rationale: Accurate surveillance of ventilator-associated pneumonia (VAP) is hampered by subjective diagnostic criteria. A novel surveillance paradigm for ventilator-associated events (VAEs) was introduced.
2014 Apr 15 - Corticosteroids Are Associated with Repression of Adaptive Immunity Gene Programs in Pediatric Septic Shock
Hector R. Wong, Natalie Z. Cvijanovich, Geoffrey L. Allen, Neal J. Thomas, Robert J. Freishtat, Nick Anas, Keith Meyer, Paul A. Checchia, Scott L. Weiss, Thomas P. Shanley, Michael T. Bigham, Sharon Banschbach, Eileen Beckman, Kelli Harmon, and Jerry J. Zimmerman Am. J. Resp. Crit. Care Med. Apr 15, 2014, vol. 189, no. 8: 940-946
Rationale: Corticosteroids are prescribed commonly for patients with septic shock, but their use remains controversial and concerns remain regarding side effects.
2014 Apr 15 - Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication
Azra Bihorac, Lakhmir S. Chawla, Andrew D. Shaw, Ali Al-Khafaji, Danielle L. Davison, George E. DeMuth, Robert Fitzgerald, Michelle Ng Gong, Derrel D. Graham, Kyle Gunnerson, Michael Heung, Saeed Jortani, Eric Kleerup, Jay L. Koyner, Kenneth Krell, Jennifer LeTourneau, Matthew Lissauer, James Miner, H. Bryant Nguyen, Luis M. Ortega, Wesley H. Self, Richard Sellman, Jing Shi, Joely Straseski, James E. Szalados, Scott T. Wilber, Michael G. Walker, Jason Wilson, Richard Wunderink, Janice Zimmerman, and John A. Kellum Am. J. Resp. Crit. Care Med. Apr 15, 2014, vol. 189, no. 8: 932-939
Rationale: We recently reported two novel biomarkers for acute kidney injury (AKI), tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), both related to G1 cell cycle arrest.
Date: 27 May 2014; Time: 8:30 - 17:30
Venue: Accident and Emergency Training Centre of TSKH, 282 Queen's Road East, WanChai, Hong Kong
Download application form here
Date: 11 Apr 2014; Time: 10:00; Activity; Visit by Department of Paediatrics and Adolescent Medicine, UCH on CIS applications in ICU
Date: 3-4 May 2014; Venue: Room N101, 1/F (New Wing), Hong Kong Convention and Exhibition Center
2014 Apr - Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study
Tone Bull Enger, Alois Philipp, Vibeke Videm, Matthias Lubnow, Alexander Wahba, Marcus Fischer, Christof Schmid, Thomas Bein, Thomas Müller Critical Care 2014, 18:R67 (9 April 2014)
Introduction: Veno-venous extracorporeal membrane oxygenation (vvECMO) can be a life-saving therapy in patients with severe acute lung failure refractory to conventional therapy. Nevertheless, vvECMO is a procedure associated with high costs and resource utilization. The aim of this study was to assess published models for prediction of mortality following vvECMO and optimize an alternative model.
2014 Apr - Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation
Akiko Oshiro, Yuichiro Yanagida, Satoshi Gando, Naomi Henzan, Isao Takahashi, Hiroshi Makise Critical Care 2014, 18:R61 (3 April 2014)
Introduction: We tested two hypotheses that disseminated intravascular coagulation (DIC) and acute coagulopathy of trauma-shock (ACOTS) in the early phase of trauma are similar disease entities and that the DIC score on admission can be used to predict the prognosis of patients with coagulopathy of trauma.
2014 Apr - Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis
Sheng-Yuan Ruan, Hsien-Ho Lin, Chun-Ta Huang, Ping-Hung Kuo, Huey-Dong Wu, Chong-Jen Yu Critical Care 2014, 18:R63 (7 April 2014)
Introduction: The effectiveness of corticosteroid therapy on the mortality of acute respiratory distress syndrome (ARDS) remains under debate. We aimed to explore the grounds for the inconsistent results in previous studies and update the evidence.
Marik PE.; Crit Care Med. 2014 Apr;42(4):962-9.
Background: Nutritional support is an essential component of the management of critically ill and injured ICU patients. Optimal provision of calories and protein has been demonstrated to reduce morbidity, mortally, and length of ICU and hospital stay. Yet, a large proportion of ICU patients receive inadequate nutrition.
2014 Apr - Liberal Versus Restricted Fluid Resuscitation Strategies in Trauma Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies
Wang CH, Hsieh WH, Chou HC, Huang YS, Shen JH, Yeo YH, Chang HE, Chen SC, Lee CC.; Crit Care Med. 2014 Apr;42(4):954-61.
Objective: Hemorrhage is responsible for most deaths that occur during the first few hours after trauma. Animal models of trauma have shown that restricting fluid administration can reduce the risk of death; however, studies in patients are difficult to conduct due to logistical and ethical problems. To maximize the value of the existing evidence, we performed a meta-analysis to compare liberal versus restricted fluid resuscitation strategies in trauma patients.
Modem V, Thompson M, Gollhofer D, Dhar AV, Quigley R.; Crit Care Med. 2014 Apr;42(4):943-53.
Objectives: Acute kidney injury and fluid overload frequently necessitate initiation of continuous renal replacement therapy in critically ill patients admitted to the ICU. In this study, our primary objective was to determine the effect of timing of initiation of continuous renal replacement therapy on ICU mortality in children requiring renal support for management of acute kidney injury and/or fluid overload.