2014 Mar - The impact of patient positioning on pressure ulcers in patients with severe ARDS: results from a multicentre randomised controlled trial on prone positioning
Girard R, Baboi L, Ayzac L, Richard JC, Guérin C; Proseva trial group.; Intensive Care Med. 2014 Mar;40(3):397-403.
PURPOSE: Placing patients with severe acute respiratory distress syndrome (ARDS) in the prone position has been shown to improve survival as compared to the supine position. However, a higher frequency of pressure ulcers has been reported in patients in the prone position. The objective of this study was to verify the impact of prone positioning on pressure ulcers in patients with severe ARDS.
2014 Mar - Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis
Beitler JR, Shaefi S, Montesi SB, Devlin A, Loring SH, Talmor D, Malhotra A.; Intensive Care Med. 2014 Mar;40(3):332-41.
PURPOSE: Prone positioning for ARDS has been performed for decades without definitive evidence of clinical benefit. A recent multicenter trial demonstrated for the first time significantly reduced mortality with prone positioning. This meta-analysis was performed to integrate these findings with existing literature and test whether differences in tidal volume explain conflicting results among randomized trials.
2014 Mar - Clinical Outcomes, Predictors, and Prevalence of Anterior Pituitary Disorders Following Traumatic Brain Injury: A Systematic Review
Lauzier F, Turgeon AF, Boutin A, Shemilt M, Côté I, Lachance O, Archambault PM, Lamontagne F, Moore L, Bernard F, Gagnon C, Cook D.; Crit Care Med. 2014 Mar;42(3):712-21.
OBJECTIVES: To assess the clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury.
Vanpee G, Hermans G, Segers J, Gosselink R.; Crit Care Med. 2014 Mar;42(3):701-11.
OBJECTIVES: To determine the reliability of volitional and nonvolitional limb muscle strength assessment in critically ill patients and to provide guidelines for the implementation of limb muscle strength assessment this population.
Dear HKSCCM members,
The next Interhospital Grand Round co-organized by the HKSCCM and HKACCN will be held on 11th March 2014 (next Tuesday). Colleagues from UCH and PWH will share their experience in managing interesting cases.
2014 Jun 11-14 - The 10th International Conference of Grief and Bereavement in Contemporary Society: Programme Overview and Concurrent Sessions in Medical Area
Date: 11-14 Jun 2014, Venue: Lee Shau Kee Lecture Centre, Centennial Campus, HKU, HKSAR
Hayley B. Gershengorn, MD; Jeremy M. Kahn, MD; Hannah Wunsch, MD CHEST March 2014; 145(3): 508-517
Background: Clinical practice guidelines recommend enteral over parenteral nutrition in critical illness and do not recommend early initiation. Few data are available on parenteral nutrition use or timing of initiation in the ICU or how this use may have changed over time.
Craig M. Lilly, MD, FCCP; John M. McLaughlin, PhD, MSPH; Huifang Zhao, PhD; Stephen P. Baker, MScPH; Shawn Cody, RN, MSN, MBA; Richard S. Irwin, MD, Master FCCP; for the UMass Memorial Critical Care Operations Group CHEST March 2014; 145(3): 500-507
Background: Few studies have evaluated both the overall effect of ICU telemedicine programs and the effect of individual components of the intervention on clinical outcomes.
Allan J. Walkey and Renda Soylemez Wiener Am. J. Resp. Crit. Care Med. Mar 1, 2014, vol. 189, no. 5: 548-555
Rationale: Processes of care are potential determinants of outcomes in patients with severe sepsis. Whether hospitals with more experience caring for patients with severe sepsis also have improved outcomes is unclear.
2014 Mar - Plasma Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis
Terpstra ML, Aman J, van Nieuw Amerongen GP, Groeneveld AB.; Crit Care Med. 2014 Mar;42(3):691-700.
OBJECTIVE: Numerous studies have focused on biomarkers for acute lung injury and acute respiratory distress syndrome. Although several biomarkers have been identified, their relative performance is unclear. We aim to provide a quantitative overview of plasma-derived biomarkers associated with acute respiratory distress syndrome diagnosis or mortality.
Parker RI.; Crit Care Med. 2014 Mar;42(3):675-90.
OBJECTIVE: To provide a concise review of transfusion-related issues and practices in the pediatric patient population, with a focus on those issues of particular importance to the care of critically ill children.
2014 Mar - B-type natriuretic Peptide and risk of acute kidney injury in patients hospitalized with acute coronary syndromes
Moltrasio M, Cabiati A, Milazzo V, Rubino M, De Metrio M, Discacciati A, Rumi P, Marana I, Marenzi G.; Crit Care Med. 2014 Mar;42(3):619-24.
OBJECTIVES: To investigate whether admission B-type natriuretic peptide levels predict the development of acute kidney injury in acute coronary syndromes.
Audimoolam VK, McPhail MJ, Wendon JA, Willars C, Bernal W, Desai SR, Auzinger G.; Crit Care Med. 2014 Mar;42(3):592-600.
OBJECTIVE: Hypoxemia is a feared complication of acute liver failure, and high oxygen requirements will frequently lead to removal of patients from the transplant list. As data regarding the prevalence and outcome of acute respiratory distress syndrome in acute liver failure are scant and hypoxemia being a commonly encountered systemic complication, we analyzed radiological, gas exchange, and ventilator data in consecutive patients admitted with acute liver failure.
2014 Mar - Pediatric and neonatal extracorporeal membrane oxygenation: does center volume impact mortality?
Freeman CL, Bennett TD, Casper TC, Larsen GY, Hubbard A, Wilkes J, Bratton SL.; Crit Care Med. 2014 Mar;42(3):512-9.
OBJECTIVE: Extracorporeal membrane oxygenation, an accepted rescue therapy for refractory cardiopulmonary failure, requires a complex multidisciplinary approach and advanced technology. Little is known about the relationship between a center's case volume and patient mortality. The purpose of this study was to analyze the relationship between hospital extracorporeal membrane oxygenation annual volume and in-hospital mortality and assess if a minimum hospital volume could be recommended.
2014 Mar - Evaluating the Efficacy and Safety of Two Doses of the Polyclonal Anti-Tumor Necrosis Factor-α Fragment Antibody AZD9773 in Adult Patients With Severe Sepsis and/or Septic Shock: Randomized, Double-Blind, Placebo-Controlled Phase IIb Study
Bernard GR, Francois B, Mira JP, Vincent JL, Dellinger RP, Russell JA, Larosa SP, Laterre PF, Levy MM, Dankner W, Schmitt N, Lindemann J, Wittebole X.; Crit Care Med. 2014 Mar;42(3):504-11.
OBJECTIVE: This trial compared the efficacy/safety of two IV doses of AZD9773, a polyclonal antibody to tumor necrosis factor-α, in adult patients with severe sepsis/septic shock.
2014 Feb - Incidence and diagnosis of ventilator-associated tracheobronchitis (VAT) in the intensive care unit: an international online survey
Alejandro Rodríguez, Pedro Póvoa, Saad Nseir, Jorge Salluh, Daniel Curcio, Ignacio Martín-Loeches Critical Care 2014, 18:R32 (12 February 2014)
Introduction: Several aspects of ventilator-associated tracheobronchitis (VAT) remain poorly defined, including diagnostic criteria, overlap with ventilator-associated pneumonia (VAP) and appropriate treatment regimens. The objective of this study was to survey reported practices in the clinical and microbiological diagnosis of VAT, and to evaluate perceptions of the impact of VAT on patient outcomes.
2014 Feb - Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review
Marcella C Müller, Joost CM Meijers, Margreeth B Vroom, Nicole P Juffermans Critical Care 2014, 18:R30 (10 February 2014)
Introduction: Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays however, have several limitations. There is a surge of interest in the use of point of care tests to diagnose hypo- and hypercoagulability in sepsis. We performed a systematic review of available literature to establish the value of rotational thromboelastography (TEG(R)) and thromboelastometry (ROTEM(R)) compared to standard coagulation tests to detect hyper- or hypocoagulability in sepsis patients. Furthermore the value of TEG(R)/ROTEM(R) to identify sepsis patients likely to benefit from therapies that interfere with the coagulation system was assessed.
2014 Feb - Characteristics of patients readmitted to intensive care unit: a nested case-control study
Tam OY, Lam SM, Shum HP, Lau CW, Chan KC, Yan WW.; Hong Kong Med J. 2014 Feb 14. [Epub ahead of print]
OBJECTIVES. To evaluate the pattern of unplanned readmissions to the intensive care unit and identify patients at risk of readmission.
Gooch RA, Kahn JM.; JAMA. 2014 Feb 12;311(6):567-8.
Intensive care is a substantial financial burden on the US health care system, with spending on critical illness exceeding $80 billion per year, approximately 3% of all health care spending and nearly 1% of the gross domestic product. In contrast, the United Kingdom spends only 0.1% of its gross domestic product on critical care services, with no evidence of worse patient outcomes and similar life expectancies as in the United States...