2016 Dec 1 - Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients
Lonneke A. van Vught, Brendon P. Scicluna, Maryse A. Wiewel, Arie J. Hoogendijk, Peter M. C. Klein Klouwenberg, Marek Franitza, Mohammad R. Toliat, Peter Nürnberg, Olaf L. Cremer, Janneke Horn, Marcus J. Schultz, Marc M. J. Bonten, and Tom van der Poll Am. J. Resp. Crit. Care Med. 1 Dec, 2016, vol 194, no. 11: 1366-1374
Rationale: Preclinical studies suggest that hospitalized patients are susceptible to infections caused by nosocomial respiratory pathogens at least in part because of immune suppression caused by the condition for which they were admitted.
2016 Dec - Venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock post-cardiac arrest
de Chambrun MP, Bréchot N, Lebreton G, Schmidt M, Hekimian G, Demondion P, Trouillet JL, Leprince P, Chastre J, Combes A, Luyt CE.; Intensive Care Med. 2016 Dec;42(12):1999-2007.
PURPOSE: To describe the characteristics, outcomes, and risk factors associated with poor outcome of venoarterial extracorporeal membrane oxygenation (VA-ECMO)-treated patients with refractory shock post-cardiac arrest.
2016 Dec - Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis
Ouweneel DM, Schotborgh JV, Limpens J, Sjauw KD, Engström AE, Lagrand WK, Cherpanath TG, Driessen AH, de Mol BA, Henriques JP.; Intensive Care Med. 2016 Dec;42(12):1922-1934.
PURPOSE: Veno-arterial extracorporeal life support (ECLS) is increasingly used in patients during cardiac arrest and cardiogenic shock, to support both cardiac and pulmonary function. We performed a systematic review and meta-analysis of cohort studies comparing mortality in patients treated with and without ECLS support in the setting of refractory cardiac arrest and cardiogenic shock complicating acute myocardial infarction.
2016 Dec - Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review
Burnham JP, Kirby JP, Kollef MH.; Intensive Care Med. 2016 Dec;42(12):1899-1911.
PURPOSE: To review the salient features of the diagnosis and management of the most common skin and soft tissue infections (SSTI). This review focuses on severe SSTIs that require care in an intensive care unit (ICU), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis.
2016 Dec - Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators and the ESICM Trials Group..; Intensive Care Med. 2016 Dec;42(12):1865-1876.
PURPOSE: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality.
2016 Nov - Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal
Liu J, Shen F, Teboul JL, Anguel N, Beurton A, Bezaz N, Richard C, Monnet X.; Crit Care. 2016 Nov 12;20(1):369.
BACKGROUND: Weaning-induced pulmonary oedema (WiPO) is a well-recognised cause of failure of weaning from mechanical ventilation, but its incidence and risk factors have not been reliably described. We wanted to determine the incidence and risk factors in a population of critically ill patients. In addition, we wanted to describe the effects of diuretics when they are administered in this context.
Smedberg M, Wernerman J.; Crit Care. 2016 Nov 10;20(1):361.
Glutamine has been launched as a conditionally indispensible amino acid for the critically ill. Supplementation has been recommended in guidelines from international societies. Although data have been presented pointing out that glutamine supplementation may not be for everybody, recommendations for treatments and design of study protocols have included all critically ill patients. Results from more recent studies and meta-analyses indicate that indiscriminate use of glutamine supplementation in critically ill patients may actually cause harm rather than beneficial effects. This viewpoint sorts out arguments of controversy in the glutamine story.
2016 Nov - Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study
Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P.; Crit Care. 2016 Nov 10;20(1):367.
BACKGROUND: Intense debate exists regarding the optimal energy and protein intake for intensive care unit (ICU) patients. However, most studies use predictive equations, demonstrated to be inaccurate to target energy intake. We sought to examine the outcome of a large cohort of ICU patients in relation to the percent of administered calories divided by resting energy expenditure (% AdCal/REE) obtained by indirect calorimetry (IC) and to protein intake.
2016 Nov 15 - Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment
Zhixin Song, Xuemei Zhang, Liping Zhang, Fang Xu, Xintong Tao, Hua Zhang, Xue Lin, Lihua Kang, Yu Xiang, Xaiofei Lai, Qun Zhang, Kun Huang, Yubing Dai, Yibing Yin, and Ju Cao Am. J. Resp. Crit. Care Med. Nov 15, 2016, vol. 194, no. 10: 1219 - 1232
Rationale: Progranulin, a widely expressed protein, has multiple physiological functions. The functional role of progranulin in the host response to sepsis remains unknown.
2016 Oct - Subglottic secretion suction for preventing ventilator-associated pneumonia: an updated meta-analysis and trial sequential analysis
Mao Z, Gao L, Wang G, Liu C, Zhao Y, Gu W, Kang H, Zhou F.; Crit Care. 2016 Oct 28;20(1):353.
BACKGROUND: Potential benefits of subglottic secretion suction for preventing ventilator-associated pneumonia (VAP) are not fully understood.
METHODS: We searched Cochrane Central, PubMed, and EMBASE up to March 2016 to identify randomized controlled trials (RCTs) that compared subglottic secretion suction versus non-subglottic secretion suction in adults with mechanical ventilation. Meta-analysis was conducted using Revman 5.3, trial sequential analysis (TSA) 0.9 and STATA 12.0. The primary outcome was incidence of VAP. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the level of evidence.
2016 Oct - Lung ultrasound: a promising tool to monitor ventilator-associated pneumonia in critically ill patients
Wang G, Ji X, Xu Y, Xiang X.; Crit Care. 2016 Oct 27;20(1):320. Review.
Ventilator-associated pneumonia (VAP) is the most frequent intensive care unit (ICU)-acquired infection that is independently associated with mortality. Accurate diagnosis and timely treatment have been shown to improve the prognosis of VAP. Chest X-ray or computed tomography imaging are used for conventional assessment of VAP, but these methods are impractical for real-time measurement in critical patients. Therefore, lung ultrasound (LUS) has been increasingly used for the assessment of VAP in the ICU.
2016 Oct - Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study
Blassmann U, Roehr AC, Frey OR, Vetter-Kerkhoff C, Thon N, Hope W, Briegel J, Huge V.; Crit Care. 2016 Oct 24;20(1):343.
BACKGROUND: Ventriculitis is a complication of temporary intraventricular drains. The limited penetration of meropenem into the cerebrospinal fluid (CSF) is well known. However, ventricular CSF pharmacokinetic data in patients with ventriculitis are lacking. The aim of this study was to evaluate meropenem pharmacokinetics in the serum and CSF of neurocritical care patients with proven or suspected ventriculitis.
2016 Oct - Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis
Fan Y, Gao F, Wu Y, Zhang J, Zhu M, Xiong L.; Crit Care. 2016 Oct 24;20(1):338.
BACKGROUND: Ventilator-associated event (VAE) is a new surveillance paradigm for monitoring complications in mechanically ventilated patients in intensive care units (ICUs). The National Healthcare Safety Network replaced traditional ventilator-associated pneumonia (VAP) surveillance with VAE surveillance in 2013. The objective of this study was to assess the consistency between VAE surveillance and traditional VAP surveillance.
Date: 13 Dec 2016; Time: 18:00-20:30; Venue: Lecture Theatre, M/F, HA Building
2016 Nov - Therapeutic hypothermia after cardiac arrest: A systematic review/meta-analysis exploring the impact of expanded criteria and targeted temperature
Schenone AL, Cohen A, Patarroyo G, Harper L, Wang X, Shishehbor MH, Menon V, Duggal A.; Resuscitation. 2016 Nov;108:102-110.
AIMS OF THE STUDY: We aimed to determine the benefit of an expanded use of TH. We also described the impact of a targeted temperature management on outcomes at discharge.
2016 Nov - Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study
Segolene Mrozek, MD; Matthieu Jabaudon, MD; Samir Jaber, MD, PhD; Catherine Paugam-Burtz, MD, PhD; Jean-Yves Lefrant, MD, PhD; Jean-Jacques Rouby, MD, PhD; Karim Asehnoune, MD, PhD; Bernard Allaouchiche, MD, PhD; Olivier Baldesi, MD; Marc Leone, MD, PhD; Qin Lu, MD, PhD; Jean-Etienne Bazin, MD, PhD; Laurence Roszyk, PharmD; Vincent Sapin, PharmD, PhD; Emmanuel Futier, MD, PhD; Bruno Pereira, PhD; Jean-Michel Constantin, MD, PhD CHEST Nov 2016; 150(5): 998-1007
Background: During ARDS, CT can reveal two distinct lung imaging patterns, focal or nonfocal, with different responses to positive end-expiratory pressure, recruitment maneuvers, and prone position. Nevertheless, their association with plasma biomarkers and their distinct functional/pathobiological mechanisms are unknown. The objective of this study was to characterize focal and nonfocal patterns of lung CT-based imaging with plasma markers of lung injury.
Sarah E. Jolley, MD; Aaron E. Bunnell, MD; Catherine L. Hough, MD CHEST Nov 2016; 150(5): 1129-1140
Survivorship after critical illness is an increasingly important health-care concern as ICU use continues to increase while ICU mortality is decreasing. Survivors of critical illness experience marked disability and impairments in physical and cognitive function that persist for years after their initial ICU stay.
2016 Sep - Prehospital therapeutic hypothermia after out-of-hospital cardiac arrest: a systematic review and meta-analysis
Nie C, Dong J, Zhang P, Liu X, Han F.; Am J Emerg Med. 2016 Sep 6.
BACKGROUND: The effectiveness and safety of the infusion of ice-cold fluids for prehospital hypothermia in cardiac arrest victims are unclear. This study assessed its effects in adult victims of out-of-hospital cardiac arrest.
Date: 16 Jan 2016; Time: 09:00 - 17:30; Venue: Nethersole Clinical Simulation Training, PYNEH