Marhong JD, Munshi L, Detsky M, Telesnicki T, Fan E. Intensive Care Med. 2015 Mar 10. [Epub ahead of print]
PURPOSE: In patients with acute respiratory distress syndrome (ARDS), extracorporeal life support (ECLS) has been utilized to support gas exchange and mitigate ventilator-induced lung injury (VILI). The optimal ventilation settings while on ECLS are unknown. The purpose of this systematic review is to describe the ventilation practices in patients with ARDS who require ECLS.
Murphy GJ, Pike K, Rogers CA, Wordsworth S, Stokes EA, Angelini GD, Reeves BC; TITRe2 Investigators. N Engl J Med. 2015 Mar 12;372(11):997-1008
BACKGROUND: Whether a restrictive threshold for hemoglobin level in red-cell transfusions, as compared with a liberal threshold, reduces postoperative morbidity and health care costs after cardiac surgery is uncertain.
2015 Mar 15 - Randomized Intubation with Polyurethane or Conical Cuffs to Prevent Pneumonia in Ventilated Patients
François Philippart, Stéphane Gaudry, Laurent Quinquis, Nicolas Lau, Islem Ouanes, Samia Touati, Jean Claude Nguyen, Catherine Branger, Frédéric Faibis, Maha Mastouri, Xavier Forceville, Fekri Abroug, Jean Damien Ricard, Sophie Grabar, and Benoît Misset Am. J. Resp. Crit. Care Med. Mar 15, 2015; vol. 191, no. 6: 637-645
Rationale: The occurrence of ventilator-associated pneumonia (VAP) is linked to the aspiration of contaminated pharyngeal secretions around the endotracheal tube. Tubes with cuffs made of polyurethane rather than polyvinyl chloride or with a conical rather than a cylindrical shape increase tracheal sealing.
2015 Feb - High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial
Wong GK, Chan DY, Siu DY, Zee BC, Poon WS, Chan MT, Gin T, Leung M; HDS-SAH Investigators.; Stroke. 2015 Feb;46(2):382-8.
BACKGROUND AND PURPOSE: Experimental evidence has indicated the benefits of simvastatin for the treatment of subarachnoid hemorrhage. Two randomized placebo-controlled pilot trials that used the highest clinically approved dose of simvastatin (80 mg daily) gave positive results despite the fact that a lower dose of simvastatin (40 mg daily) did not improve clinical outcomes. We hypothesized that a high dose of 80 mg of simvastatin daily for 3 weeks would reduce the incidence of delayed ischemic deficits after subarachnoid hemorrhage compared with a lower dose (40 mg of simvastatin daily) and lead to improved clinical outcomes.
Phua J, Joynt GM, Nishimura M, Deng Y, Myatra SN, Chan YH, Binh NG, Tan CC, Faruq MO, Arabi YM, Wahjuprajitno B, Liu SF, Hashemian SM, Kashif W, Staworn D, Palo JE, Koh Y; ACME Study Investigators and the Asian Critical Care Clinical Trials Group.; JAMA Intern Med. 2015 Mar 1;175(3):363-71.
IMPORTANCE: Little data exist on end-of-life care practices in intensive care units (ICUs) in Asia.
OBJECTIVE: To describe physicians' attitudes toward withholding and withdrawal of life-sustaining treatments in end-of-life care and to evaluate factors associated with observed attitudes.
Cheng VC, Tai JW, Lee WM, Chan WM, Wong SC, Chen JH, Poon RW, To KK, Chan JF, Ho PL, Chan KH, Yuen KY.; Infect Control Hosp Epidemiol. 2015 Jan;36(1):87-92.
OBJECTIVE: To assess the effectiveness of infection control preparedness for human infection with influenza A H7N9 in Hong Kong.
Boland TA, Lee VH, Bleck TP. ;Crit Care Med. 2015 Mar;43(3):686-93.
Objectives: Reversible stress-induced cardiac dysfunction is frequently seen as a complication of a multitude of acute stress states, in particular neurologic injuries. This dysfunction may be difficult to distinguish between that caused by myocardial ischemia and may impact both the treatment strategies and prognosis of the underlying condition. Critical care practitioners should have an understanding of the epidemiology, pathophysiology, clinical characteristics, precipitating conditions, differential diagnosis, and proposed treatments for stress-induced cardiomyopathy.
2015 Mar - Mechanical Ventilation Management During Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: A Retrospective International Multicenter Study
Schmidt M, Stewart C, Bailey M, Nieszkowska A, Kelly J, Murphy L, Pilcher D, Cooper DJ, Scheinkestel C, Pellegrino V, Forrest P, Combes A, Hodgson C.; Crit Care Med. 2015 Mar;43(3):654-64.
Objective: To describe mechanical ventilation settings in adult patients treated for an acute respiratory distress syndrome with extracorporeal membrane oxygenation and assess the potential impact of mechanical ventilation settings on ICU mortality.
Date: 25 and 25 Apr 2015; Venue: Ballroom Langham Place Hotel Mongkok
2015 Mar - Comparison of Video Laryngoscopy Versus Direct Laryngoscopy During Urgent Endotracheal Intubation: A Randomized Controlled Trial
Silverberg MJ, Li N, Acquah SO, Kory PD. ;Crit Care Med. 2015 Mar;43(3):636-41.
Objectives: In the critically ill undergoing urgent endotracheal intubation by direct laryngoscopy, multiple attempts are often required with a higher complication rate due to the urgency, uncontrolled setting, comorbidities, and variability in expertise of operators. We hypothesized that Glidescope video laryngoscopy would be superior to direct laryngoscopy during urgent endotracheal intubation.
2015 Mar - Use of High-Flow Nasal Cannula Oxygen Therapy to Prevent Desaturation During Tracheal Intubation of Intensive Care Patients With Mild-to-Moderate Hypoxemia
Miguel-Montanes R, Hajage D, Messika J, Bertrand F, Gaudry S, Rafat C, Labbé V, Dufour N, Jean-Baptiste S, Bedet A, Dreyfuss D, Ricard JD.; Crit Care Med. 2015 Mar;43(3):574-83.
Objectives: Tracheal intubation of ICU patients is frequently associated with severe hypoxemia. Although noninvasive ventilation reduces desaturation during intubation of severely hypoxemic patients, it does not allow for per-procedure oxygenation and has not been evaluated in mild-to-moderate hypoxemic patients for whom high-flow nasal cannula oxygen may be an alternative. We sought to compare pre- and per-procedure oxygenation with either a nonrebreathing bag reservoir facemask or a high-flow nasal cannula oxygen during tracheal intubation of ICU patients.
Date: 11 and 12 Apr 2015; Venue: Lecture Theatre 4, Cheung Kung Hai Conference Centre, William MW Mong Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
Date: 22/6/2015, Venue: Room 301, 3/F Li Ka Shing Medical Science Building, PWH, Shatin
2015 Mar - Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the acetaminophen for the reduction of oxidative injury in severe sepsis trial
Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ 2nd, Ware LB; Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis Study Group.; Crit Care Med. 2015 Mar;43(3):534-41
Objectives: This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin.
2015 Mar - The role of aerosolized colistin in the treatment of ventilator-associated pneumonia: a systematic review and metaanalysis
Valachis A, Samonis G, Kofteridis DP. Crit Care Med. 2015 Mar;43(3):527-33.
OBJECTIVES: The present meta-analysis and systematic review evaluated the efficacy and safety of aerosolized colistin as adjunctive therapy to IV antimicrobials or as monotherapy in the treatment of ventilator-associated pneumonia.
2015 Mar - The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis
Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE, Hébert P, Cook DJ, Fergusson DA; Canadian Critical Care Trials Group.; Crit Care Med. 2015 Mar;43(3):511-8.
OBJECTIVE: To evaluate the efficacy and safety of heparin in patients with sepsis, septic shock, or disseminated intravascular coagulation associated with infection.
2014 Nov - Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus
Lai KY, Ng WY, Cheng FF.; Infect Dis Poverty. 2014 Nov 28;3:43.
The recent outbreak of the human Zaire ebolavirus (EBOV) epidemic is spiraling out of control in West Africa. Human EBOV hemorrhagic fever has a case fatality rate of up to 90%. The EBOV is classified as a biosafety level 4 pathogen and is considered a category A agent of bioterrorism by Centers for Disease Control and Prevention, with no approved therapies and vaccines available for its treatment apart from supportive care...
2015 Mar - Assessing the Utility of ICU Readmissions as a Quality Metric: An Analysis of Changes Mediated by Residency Work-Hour Reforms
Sydney E. S. Brown, MD, PhD; Sarah J. Ratcliffe, PhD; Scott D. Halpern, MD, PhD CHEST Mar 2015; 147(3): 626-636
BACKGROUND: ICU readmissions are associated with increased mortality and costs; however, it is unclear whether these outcomes are caused by readmissions or by residual confounding by illness severity. An assessment of temporal changes in ICU readmission in response to a specific policy change could help disentangle these possibilities. We sought to determine whether ICU readmission rates changed after 2003 Accreditation Council for Graduate Medical Education Resident Duty Hours reform (“reform”) and whether there were temporally corresponding changes in other ICU outcomes.